Title : Anticancer effect of AZD2461 PARP inhibitor against colon cancer cells carrying wt or dysfunctional p53.

Pub. Date : 2021 Nov 15

PMID : 34653407






1 Functional Relationships(s)
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1 We found that AZD2461 reduced cell proliferation in wtp53 and p53-/- cancer cells by increasing ROS and DNA damage, while R273H mutant (mut) p53 counteracted these effects. ros tumor protein p53 Homo sapiens