Title : Tumor-activatable biomineralized nanotherapeutics for integrative glucose starvation and sensitized metformin therapy.

Pub. Date : 2021 Nov

PMID : 34649197






1 Functional Relationships(s)
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1 The selective glucose deprivation would not only disrupt tumor energy metabolism, but also upregulate the PP2A regulatory subunit B56delta and sensitize tumor cells to the metformin-induced CIP2A inhibition, leading to efficient apoptosis induction via PP2A-GSK3beta-MCL-1 axis with negligible side effects. Metformin glycogen synthase kinase 3 alpha Homo sapiens