Title : Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling.

Pub. Date : 2021 Nov 3

PMID : 34647720






1 Functional Relationships(s)
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1 In the present study, we have demonstrated that pharmacological inhibition of mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) by mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor (PD98059) restored the expression of a disintegrin and metalloproteinase 10 (ADAM10) with a concomitant decrease in beta-site APP cleavage enzyme 1 (BACE1) under oxidative stress. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one Eph receptor B1 Rattus norvegicus