Title : Nitro-Deficient Niclosamide Confers Reduced Genotoxicity and Retains Mitochondrial Uncoupling Activity for Cancer Therapy.

Pub. Date : 2021 Sep 27

PMID : 34638761






2 Functional Relationships(s)
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1 Previously, we reported that niclosamide targets a metabolic vulnerability in p53-deficient tumours, providing a basis for patient stratification and personalised treatment strategies. Niclosamide tumor protein p53 Homo sapiens
2 Notably, quantitative scoring of drug sensitivity suggests that elimination of its nitro group enhanced the target selectivity of niclosamide against p53 deficiency. Niclosamide tumor protein p53 Homo sapiens