Title : p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4.

Pub. Date : 2022 Mar

PMID : 34628485






2 Functional Relationships(s)
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1 Here, we show that p53 functions to support repair and recovery from CCl4-mediated liver damage, control reactive oxygen species (ROS) and limit the development of hepatocellular carcinoma (HCC), in part through the activation of a detoxification cytochrome P450, CYP2A5 (CYP2A6 in humans). Reactive Oxygen Species tumor protein p53 Homo sapiens
2 Here, we show that p53 functions to support repair and recovery from CCl4-mediated liver damage, control reactive oxygen species (ROS) and limit the development of hepatocellular carcinoma (HCC), in part through the activation of a detoxification cytochrome P450, CYP2A5 (CYP2A6 in humans). Reactive Oxygen Species tumor protein p53 Homo sapiens