Title : CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer.

Pub. Date : 2021 Dec

PMID : 34621019






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cholesterol and geranylgeranyl diphosphate (GGPP) rescued the growth inhibitory and signaling effect of HMGCR/FDPS blockade, implying a direct role of these metabolites in modulating stemness. geranylgeranyl pyrophosphate 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens
2 Cholesterol and geranylgeranyl diphosphate (GGPP) rescued the growth inhibitory and signaling effect of HMGCR/FDPS blockade, implying a direct role of these metabolites in modulating stemness. geranylgeranyl pyrophosphate 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens