Title : Rac1/pSTAT3 expression: A pharmacodynamic marker panel as a first step toward optimization of thiopurine therapy in inflammatory bowel disease patients.

Pub. Date : 2022 Feb

PMID : 34595833






2 Functional Relationships(s)
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Protein Name
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1 The active thiopurine metabolite 6-thioguanine triphosphate (6-Thio-GTP) causes T cell apoptosis via Rac1 and the downstream transcription factor signal transducer and activator of transcription 3 (STAT3). 2-mercaptopyrazine signal transducer and activator of transcription 3 Homo sapiens
2 The active thiopurine metabolite 6-thioguanine triphosphate (6-Thio-GTP) causes T cell apoptosis via Rac1 and the downstream transcription factor signal transducer and activator of transcription 3 (STAT3). 2-mercaptopyrazine signal transducer and activator of transcription 3 Homo sapiens