Title : Impact of immune checkpoint molecules on FoxP3+ Treg cells and related cytokines in patients with acute and chronic brucellosis.

Pub. Date : 2021 Sep 30

PMID : 34592958






2 Functional Relationships(s)
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1 RESULTS: The frequency of Tregs was higher in chronic patients than in healthy controls (P = 0.026) and acute patients (P = 0.042); The frequency of CTLA-4+ Tregs in chronic patients was significantly higher than that in healthy controls (P = 0.011). tregs cytotoxic T-lymphocyte associated protein 4 Homo sapiens
2 CTLA-4 and TGF-beta1 may contribute to Tregs-mediated immunosuppression in the chronic infection stage of a Brucella infection. tregs cytotoxic T-lymphocyte associated protein 4 Homo sapiens