Title : ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5.

Pub. Date : 2021 Oct

PMID : 34589798






1 Functional Relationships(s)
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1 Together, the St3gal5-/- mice display ASD-like behavioural features, altered response to systemic inflammation, signs of hypomyelination and neuroinflammation, which suggests that deficiency in a- and b-series gangliosides could contribute to the development of an ASD-like pathology in humans. Gangliosides ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Mus musculus