Title : Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10-/- model of colitis.

Pub. Date : 2022 Mar

PMID : 34588632






1 Functional Relationships(s)
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Protein Name
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1 Foxo3a signaling represses the transcription of glutaminase (GLS/GLS2) to prevent over-consumption of glutamine by activated T cells and its conversion to glutamate that contributes to the TCA cycle and mTORC1 activation. Glutamine CREB regulated transcription coactivator 1 Mus musculus