Pub. Date : 2021 Sep 29
PMID : 34587977
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gene knockdown/overexpression, MTT and mouse cancer models were used to examine the role of INMT as well as the anticancer efficacy of INMT inhibitor N,N-dimethyltryptamine (DMT), the SMYD3 inhibitor BCl-12, the selenium compounds methaneseleninic acid (MSA) and Se-(Methyl)selenocysteine hydrochloride (MSC), and the newly identified endogenous INMT substrate Bis(7)-tacrine. | 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine | indolethylamine N-methyltransferase | Mus musculus |
| 2 | Importantly, INMT knockdown significantly increased the anticancer effect of the exogenous selenium compounds methaneseleninic acid (MSA) and Se-(Methyl)selenocysteine hydrochloride (MSC) as well as the endogenous metabolite Bis(7)-tacrine. | 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine | indolethylamine N-methyltransferase | Mus musculus |