Pub. Date : 2021 Sep 7
PMID : 34571995
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in glioma, which result in the accumulation of an "oncometabolite", D-2-hydroxyglutarate (D-2-HG). | alpha-hydroxyglutarate | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in glioma, which result in the accumulation of an "oncometabolite", D-2-hydroxyglutarate (D-2-HG). | alpha-hydroxyglutarate | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | Recent studies have revealed that D-2-HG affects DNA/histone methylation, hypoxia signaling, DNA repair, and redox homeostasis, which impacts the oncogenesis of IDH-mutated cancers. | alpha-hydroxyglutarate | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |