Pub. Date : 2021
PMID : 34567221
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Idebenone-Activating Autophagic Degradation of alpha-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson"s Disease: A Network Pharmacological Approach. | idebenone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The enrichment analysis highlighted manipulation of MAP kinase activity and the PI3K-AKT signaling pathway as potential pharmacological targets for Idebenone against PD. | idebenone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Additionally, molecular docking showed that AKT and MAPK could bind tightly with Idebenone. | idebenone | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | In the cell model of PD, Idebenone activated autophagy and promoted alpha-synuclein degradation by suppressing the AKT/mTOR pathway. | idebenone | AKT serine/threonine kinase 1 | Homo sapiens |