Title : Protective Mechanism of Luteinizing Hormone and Follicle-Stimulating Hormone Against Nicotine-Induced Damage of Mouse Early Folliculogenesis.

Pub. Date : 2021

PMID : 34557491






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1 Protective Mechanism of Luteinizing Hormone and Follicle-Stimulating Hormone Against Nicotine-Induced Damage of Mouse Early Folliculogenesis. Nicotine follicle stimulating hormone beta Mus musculus
2 In this paper, we discovered that luteinizing hormone (LH) and follicle-stimulating hormone (FSH) could counteract the damage caused by nicotine of mouse germ cell cyst breakdown. Nicotine follicle stimulating hormone beta Mus musculus
3 In this paper, we discovered that luteinizing hormone (LH) and follicle-stimulating hormone (FSH) could counteract the damage caused by nicotine of mouse germ cell cyst breakdown. Nicotine follicle stimulating hormone beta Mus musculus
4 Compared with the nicotine group, the quality of oocytes and the number of follicles were remarkably increased in the nicotine plus LH group or nicotine plus FSH group. Nicotine follicle stimulating hormone beta Mus musculus
5 LH and FSH could alleviate nicotine-induced oocyte autophagy by different pathways. Nicotine follicle stimulating hormone beta Mus musculus
6 LH reduced the nicotine-induced autophagy by restoring the phosphorylation level of adenosine 5"-monophosphate-activated protein kinase alpha-1, while FSH by downregulating the phosphorylation level of Forkhead box class O 1. Nicotine follicle stimulating hormone beta Mus musculus
7 Taken together, these results suggested that LH and FSH could counteract the damage caused by nicotine and finally ensure normal germ cell cyst breakdown and early embryo development. Nicotine follicle stimulating hormone beta Mus musculus