Pub. Date : 2022 Mar
PMID : 34546489
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Irisin alleviates FFA induced beta-cell insulin resistance and inflammatory response through activating PI3K/AKT/FOXO1 signaling pathway. | irisin | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Moreover, irisin improved PI3K/AKT insulin signaling pathway and inhibited TLR4/NF-kappaB inflammatory signaling pathway in both islets of HFD mice and PA-treated MIN6 cells. | irisin | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | CONCLUSION: Irisin alleviates lipotoxicity-induced beta-cell insulin resistance and inflammatory response through the activation of PI3K/AKT/FOXO1 signaling pathways and the inhibition of TLR4/NF-kappaB signaling pathways. | irisin | thymoma viral proto-oncogene 1 | Mus musculus |