Pub. Date : 2021
PMID : 34541552
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reactivation of inhibited hAChE can be achieved with nucleophilic antidotes, such as oximes. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Here we report X-ray structures of hAChE conjugated with a reversible covalent inhibitor 4K-TMA (4K-TMA:hAChE) at 2.8 A resolution and of 4K-TMA:hAChE conjugate with oxime reactivator methoxime, MMB4 (4K-TMA:hAChE:MMB4) at 2.6 A resolution, both at physiologically relevant room temperature, as well as cryo-crystallographic structure of 4K-TMA:hAChE at 2.4 A resolution. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |