Pub. Date : 2021
PMID : 34541552
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acetylcholinesterase (AChE) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. | Acetylcholine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Acetylcholinesterase (AChE) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. | Acetylcholine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | 4K-TMA acts as a substrate analogue reacting with the hydroxyl of Ser203 and generating a reversible tetrahedral hemiketal intermediate that closely resembles the first tetrahedral intermediate state during hAChE-catalyzed acetylcholine hydrolysis. | Acetylcholine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | The active center geometry of AChE, already highly evolved for the efficient catalysis, was thus indicative of only minor conformational adjustments to accommodate the tetrahedral intermediate in the hydrolysis of the neurotransmitter acetylcholine (ACh). | Acetylcholine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | The active center geometry of AChE, already highly evolved for the efficient catalysis, was thus indicative of only minor conformational adjustments to accommodate the tetrahedral intermediate in the hydrolysis of the neurotransmitter acetylcholine (ACh). | Acetylcholine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |