Title : Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK.

Pub. Date : 2022 Apr

PMID : 34536415






1 Functional Relationships(s)
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1 RESULTS: Mutant HCK lacking the C-terminal inhibitory tyrosine Tyr522 exhibited increased kinase activity and enhanced myeloid cell priming, migration and effector functions, such as production of the inflammatory cytokines IL-1beta, IL-6, IL-8 and TNFalpha and production of reactive oxygen species. Tyrosine tumor necrosis factor Homo sapiens