Title : Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance.

Pub. Date : 2022 Jan

PMID : 34534538






1 Functional Relationships(s)
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Protein Name
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1 Gemcitabine treatment led to MUC5AC overexpression, resulting in disruption of E-Cadherin/beta-catenin junctions and the nuclear translocation of beta-catenin, which increased c-Myc expression with a concomitant rise in glutamine uptake and glutamate release. gemcitabine cadherin 1 Homo sapiens