Title : The balance between NAD+ biosynthesis and consumption in ageing.

Pub. Date : 2021 Oct

PMID : 34509469






3 Functional Relationships(s)
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1 NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. NAD CD38 molecule Homo sapiens
2 Decreasing tissue NAD+ concentrations have been ascribed to an imbalance between biosynthesis and consumption of the dinucleotide, resulting from, for instance, reduced levels of the rate limiting enzyme NAMPT along with an increased activation state of the NAD+-consuming enzymes PARPs and CD38. NAD CD38 molecule Homo sapiens
3 Decreasing tissue NAD+ concentrations have been ascribed to an imbalance between biosynthesis and consumption of the dinucleotide, resulting from, for instance, reduced levels of the rate limiting enzyme NAMPT along with an increased activation state of the NAD+-consuming enzymes PARPs and CD38. NAD CD38 molecule Homo sapiens