Title : Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites.

Pub. Date : 2021 Dec

PMID : 34503974






3 Functional Relationships(s)
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Protein Name
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1 Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites. remdesivir solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
2 In vitro transport experiments demonstrated that remdesivir was the most potent inhibitor of ENT-mediated (3H) uridine uptake (ENT1 IC50: 38.65 mM; ENT2 IC50: 76.72 mM), followed by EIDD-1931 (ENT1 IC50: 258.9 mM; ENT2 IC50: 467.3 mM), while molnupiravir was a modest inhibitor (ENT1 IC50: 701.0 mM; ENT2 IC50: 851.4 mM). remdesivir solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
3 Significance Statement Significance statement: This study identified remdesivir and EIDD-1931 as substrates of equilibrative nucleoside transporters 1 and 2. remdesivir solute carrier family 29 member 1 (Augustine blood group) Homo sapiens