Pub. Date : 2021 Dec
PMID : 34503974
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites. | remdesivir | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
2 | In vitro transport experiments demonstrated that remdesivir was the most potent inhibitor of ENT-mediated (3H) uridine uptake (ENT1 IC50: 38.65 mM; ENT2 IC50: 76.72 mM), followed by EIDD-1931 (ENT1 IC50: 258.9 mM; ENT2 IC50: 467.3 mM), while molnupiravir was a modest inhibitor (ENT1 IC50: 701.0 mM; ENT2 IC50: 851.4 mM). | remdesivir | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
3 | Significance Statement Significance statement: This study identified remdesivir and EIDD-1931 as substrates of equilibrative nucleoside transporters 1 and 2. | remdesivir | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |