Title : The Antihypertensive Drug Telmisartan Protects Oligodendrocytes from Cholesterol Accumulation and Promotes Differentiation by a PPAR-γ-Mediated Mechanism.

Pub. Date : 2021 Aug 30

PMID : 34502342






2 Functional Relationships(s)
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1 Furthermore, TLM can offset the OP maturation arrest induced by a lysosomal cholesterol transport inhibitor (U18666A), which reproduces an NPC1-like phenotype. Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens
2 In the NPC1 model, TLM also reduces cholesterol accumulation within peroxisomal and lysosomal compartments and the contacts between lysosomes and peroxisomes, revealing that TLM can regulate intracellular cholesterol transport, crucial for myelin formation. Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens