Title : Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine.

Pub. Date : 2021 Nov 1

PMID : 34499080






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine. Arginine C9orf72-SMCR8 complex subunit Homo sapiens
2 Arg (R)-rich dipeptide repeat proteins (DPRs; poly(PR): Pro-Arg and poly(GR): Gly-Arg), encoded by a hexanucleotide expansion in the C9ORF72 gene, induce neurodegeneration in amyotrophic lateral sclerosis (ALS). Arginine C9orf72-SMCR8 complex subunit Homo sapiens