Pub. Date : 2021 Dec
PMID : 34486197
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HGF/c-MET pathway contributes to cisplatin-mediated PD-L1 expression in hepatocellular carcinoma. | Cisplatin | CD274 molecule | Homo sapiens |
| 2 | Cisplatin has been reported to promote the expression of PD-L1 in some cancer cells. | Cisplatin | CD274 molecule | Homo sapiens |
| 3 | However, the underlying mechanism through which PD-L1 is transcriptionally regulated by cisplatin in HCC cells remains largely unknown. | Cisplatin | CD274 molecule | Homo sapiens |
| 4 | In the present study, we found that the expression of HGF, p-Akt, p-ERK, and PD-L1 was increased in cisplatin-treated SNU-368 and SNU-739 cells. | Cisplatin | CD274 molecule | Homo sapiens |
| 5 | Moreover, Inhibition of HGF/c-MET, PI3K/Akt, and MEK/ERK signaling pathways can dramatically block cisplatin or HGF-induced PD-L1 expression in SNU-368 and SNU-739 cells. | Cisplatin | CD274 molecule | Homo sapiens |
| 6 | Taken together, our study suggested that HGF/c-Met axis-induced the activation of PI3K/Akt and MEK/ERK pathways contributes to cisplatin-mediated PD-L1 expression. | Cisplatin | CD274 molecule | Homo sapiens |