CPRiL

4 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	Curcumin	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2
2	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	Curcumin	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2
3	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	Curcumin	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2
4	CONCLUSION: This result provides a significant insight about the phytochemicals" role, namely curcumin and piperine, as the potential therapeutic entities against mutated spike protein of SARS-CoV-2.	Curcumin	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2