Pub. Date : 2022 Jan
PMID : 34478763
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HBx suppressed the HR repair of DSBs, including that induced by the clustered regularly interspaced short palindromic repeats-Cas9 system, in an Smc5/6-dependent manner, which was rescued by restoring the Smc5/6 complex. | dsbs | X protein | Hepatitis B virus |
| 2 | CONCLUSIONS: Degradation of the Smc5/6 complex by HBx increases viral transcription and promotes cellular transformation by impairing HR repair of DSBs. | dsbs | X protein | Hepatitis B virus |