Pub. Date : 2022 Mar 26
PMID : 34478556
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine metabolism predicted by CYP2A6 genotypes in relation to smoking cessation: A systematic review. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | Of major interest is genetic variation in nicotine metabolism, largely predicted by CYP2A6 variations. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | METHODS: We conducted a systematic literature review to summarize the population-based evidence of the association between CYP2A6 and smoking cessation.In the 12 studies meeting the inclusion criteria, the known functional metabolic effect of CYP2A6 variants was used to classify nicotine metabolism as normal (>75% metabolic activity), intermediate (50.1 - 75% activity), slow (25 - 50% activity), and poor (<25% activity). | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 4 | RESULTS: Among untreated people of European ancestry (n = 4 studies), those with CYP2A6 reduced metabolism were more likely to quit smoking than those with normal metabolism (Summary OR = 2.05, 95% CI 1.23 - 3.42) and the likelihood of cessation increased as nicotine metabolism decreased. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |