Pub. Date : 2021 Oct 26
PMID : 34478523
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Deficiency of SMS1, but not SMS2, prevented SM production and enhanced phosphatidylserine (PS) externalization on the plasma membranes of platelets and megakaryocytes. | Phosphatidylserines | sphingomyelin synthase 1 | Mus musculus |
| 2 | Deficiency of SMS1, but not SMS2, prevented SM production and enhanced phosphatidylserine (PS) externalization on the plasma membranes of platelets and megakaryocytes. | Phosphatidylserines | sphingomyelin synthase 1 | Mus musculus |
| 3 | SMS1-KO tMEFs in which TMEM16F was knocked out using the CRISPR-Cas9 system lacked both the Ca2+ influx and excess PS exposure seen in SMS1-KO tMEFs. | Phosphatidylserines | sphingomyelin synthase 1 | Mus musculus |
| 4 | Therefore, SM depletion on platelet membrane microdomains due to SMS1 deficiency enhanced PS externalization via a Ca2+ influx through TMEM16F activation, leading to elevated platelet clearance and causing hemostasis dysfunction through thrombocytopenia. | Phosphatidylserines | sphingomyelin synthase 1 | Mus musculus |