Pub. Date : 2021 Aug 30
PMID : 34462431
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, we obtain evidence suggesting that serum uridine is a key factor in determining the efficacy of therapeutic agents that target DHODH. | Uridine | dihydroorotate dehydrogenase (quinone) | Homo sapiens |
| 2 | In the presence of physiological concentrations of uridine, neuroblastoma cell lines are highly resistant to DHODH inhibition. | Uridine | dihydroorotate dehydrogenase (quinone) | Homo sapiens |
| 3 | This uridine-dependent resistance to DHODH inhibitors can be abrogated by dipyridamole, an FDA-approved drug that blocks nucleoside transport. | Uridine | dihydroorotate dehydrogenase (quinone) | Homo sapiens |