Title : Influence of NQO1 Polymorphisms on Warfarin Maintenance Dose: A Systematic Review and Meta-Analysis (rs1800566 and rs10517).

Pub. Date : 2021

PMID : 34457036






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Influence of NQO1 Polymorphisms on Warfarin Maintenance Dose: A Systematic Review and Meta-Analysis (rs1800566 and rs10517). Warfarin NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 This meta-analysis was conducted to analyze the effect of NQO1 polymorphism on the warfarin maintenance dosage. Warfarin NAD(P)H quinone dehydrogenase 1 Homo sapiens
3 Review Manager Version 5.4 software was used to analyze the relationship between NQO1 polymorphisms and the warfarin maintenance dosage. Warfarin NAD(P)H quinone dehydrogenase 1 Homo sapiens
4 Patients who were NQO1 rs10517 G carriers (AG carriers or GG carriers) required a 48% higher warfarin maintenance dose than those who were AA carriers. Warfarin NAD(P)H quinone dehydrogenase 1 Homo sapiens
5 Patients with NQO1 rs1800566 CT carriers required a 13% higher warfarin dose than those who were CC carriers, with no associations observed with the other comparisons of the NQO1 rs1800566 genotypes. Warfarin NAD(P)H quinone dehydrogenase 1 Homo sapiens
6 Our meta-analysis suggests that the NQO1 rs10517and NQO1 rs1800566 variant statuses affect the required warfarin maintenance dose. Warfarin NAD(P)H quinone dehydrogenase 1 Homo sapiens
7 Our meta-analysis suggests that the NQO1 rs10517and NQO1 rs1800566 variant statuses affect the required warfarin maintenance dose. Warfarin NAD(P)H quinone dehydrogenase 1 Homo sapiens