Title : Nox2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection.

Pub. Date : 2021 Oct

PMID : 34454164






5 Functional Relationships(s)
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1 NOX2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection. Superoxides cytochrome b-245, beta polypeptide Mus musculus
2 Macrophages derived from Nox2-deficient (gp91phox-/-) mice produced marginal amounts of superoxide radical and were more susceptible to parasite infection than those derived from wild type (wt) animals. Superoxides cytochrome b-245, beta polypeptide Mus musculus
3 Macrophages derived from Nox2-deficient (gp91phox-/-) mice produced marginal amounts of superoxide radical and were more susceptible to parasite infection than those derived from wild type (wt) animals. Superoxides cytochrome b-245, beta polypeptide Mus musculus
4 Biochemical or genetic reconstitution of intraphagosomal superoxide radical formation in gp91phox-/- macrophages reverted the lack of control of infection. Superoxides cytochrome b-245, beta polypeptide Mus musculus
5 Thus, this work supports that Nox2-derived superoxide radical plays a crucial role to control T. cruzi infection in the early phase of a murine model of Chagas disease. Superoxides cytochrome b-245, beta polypeptide Mus musculus