Pub. Date : 2021 Oct
PMID : 34454164
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NOX2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 2 | Macrophages derived from Nox2-deficient (gp91phox-/-) mice produced marginal amounts of superoxide radical and were more susceptible to parasite infection than those derived from wild type (wt) animals. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 3 | Macrophages derived from Nox2-deficient (gp91phox-/-) mice produced marginal amounts of superoxide radical and were more susceptible to parasite infection than those derived from wild type (wt) animals. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 4 | Biochemical or genetic reconstitution of intraphagosomal superoxide radical formation in gp91phox-/- macrophages reverted the lack of control of infection. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |
| 5 | Thus, this work supports that Nox2-derived superoxide radical plays a crucial role to control T. cruzi infection in the early phase of a murine model of Chagas disease. | Superoxides | cytochrome b-245, beta polypeptide | Mus musculus |