Title : Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics.

Pub. Date : 2021 Aug 12

PMID : 34452207






1 Functional Relationships(s)
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1 Hypoxia is a complex microenvironmental condition known to regulate choline kinase alpha (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha) and, therefore, may confound the uptake of choline radiotracer (18F)fluoromethyl-(1,2-2H4)-choline ((18F)-D4-FCH). Choline choline kinase alpha Homo sapiens