Title : Effects of 1α,25-Dihydroxyvitamin D3 on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach.

Pub. Date : 2021 Jul 25

PMID : 34452094






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The mRNA expression of rOCT1 in the kidneys was significantly increased in 1,25(OH)2D3-treated rats compared with the control rats, while the mRNA expressions of rOCT2 and rMATE1 in the kidneys, rOCT1 and N-acetyltransferase-II (NAT-II) in the liver, and rOCT3 in the heart were significantly decreased. methyl 5-methyl-3-(1,2-oxazol-5-yl)-1H-pyrazole-4-carboxylate solute carrier family 47 member 1 Rattus norvegicus