Title : Reactivity of Thiol-Rich Zn Sites in Diacylglycerol-Sensing PKC C1 Domain Probed by NMR Spectroscopy.

Pub. Date : 2021

PMID : 34447788






2 Functional Relationships(s)
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1 We find that even in the presence of the oxygen-rich sites presented by the neighboring peripheral membrane-binding C2 domain, the thiol-rich sites can successfully compete for the available Cd2+. Sulfhydryl Compounds CD2 molecule Homo sapiens
2 Our results indicate that Cd2+ can target the entire membrane-binding regulatory region of PKCs, and that the competition between the thiol- and oxygen-rich sites will likely determine the activation pattern of PKCs. Sulfhydryl Compounds CD2 molecule Homo sapiens