Pub. Date : 2021 Aug 17
PMID : 34445564
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NPC proteins are deputed to transport cholesterol within lysosomes or between late endosome/lysosome systems and other cellular compartments, such as the endoplasmic reticulum and plasma membrane. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | The first trait of NPC is the accumulation of unesterified cholesterol and other lipids, like sphingosine and glycosphingolipids, in the late endosomal and lysosomal compartments, which causes the blockade of autophagic flux and the impairment of mitochondrial functions. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |