Title : Myelin Defects in Niemann-Pick Type C Disease: Mechanisms and Possible Therapeutic Perspectives.

Pub. Date : 2021 Aug 17

PMID : 34445564






1 Functional Relationships(s)
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1 The first trait of NPC is the accumulation of unesterified cholesterol and other lipids, like sphingosine and glycosphingolipids, in the late endosomal and lysosomal compartments, which causes the blockade of autophagic flux and the impairment of mitochondrial functions. Sphingosine NPC intracellular cholesterol transporter 1 Homo sapiens