Pub. Date : 2021 Aug 16
PMID : 34445495
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Previously, we have demonstrated that the combined inhibition of EGFR and MDM2-p53 pathways, by gefitinib and JNJ-26854165, exerts a strong synergistic lethal effect on HGSOC cells. | Gefitinib | tumor protein p53 | Homo sapiens |
2 | The targeted inhibition responses of gefitinib and JNJ-26854165, in p53R248Q-overexpressing cells, were extensively evaluated. | Gefitinib | tumor protein p53 | Homo sapiens |
3 | Next, we analyzed the gefitinib and JNJ-26854165 responses and found differential sensitivity to the single- or combined-drug inhibitions in p53R248Q-overexpressing cells. | Gefitinib | tumor protein p53 | Homo sapiens |