Title : Negative impacts of microcystin-LR and glyphosate on zebrafish intestine: Linked with gut microbiota and microRNAs?

Pub. Date : 2021 Oct 1

PMID : 34438504






2 Functional Relationships(s)
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1 In the current study, a subacute toxicity test of zebrafish exposed to MC-LR (35 mug L-1) and GLY (3.5 mg L-1), either alone or in combination was performed for 21 d. The results showed that MC-LR or/and GLY treatment reduced the mRNA levels of tight junction genes (claudin-5, occludin, and zonula occludens-1) and altered the levels of diamine oxidase and D-lactic, indicating increased intestinal permeability in zebrafish. cyanoginosin LR amine oxidase copper containing 1 Danio rerio
2 In the current study, a subacute toxicity test of zebrafish exposed to MC-LR (35 mug L-1) and GLY (3.5 mg L-1), either alone or in combination was performed for 21 d. The results showed that MC-LR or/and GLY treatment reduced the mRNA levels of tight junction genes (claudin-5, occludin, and zonula occludens-1) and altered the levels of diamine oxidase and D-lactic, indicating increased intestinal permeability in zebrafish. cyanoginosin LR amine oxidase copper containing 1 Danio rerio