Pub. Date : 2021 Dec
PMID : 34432352
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pretreatment with metformin prevents microcystin-LR-induced tau hyperphosphorylation via mTOR-dependent PP2A and GSK-3beta activation. | Metformin | glycogen synthase kinase 3 alpha | Homo sapiens |
| 2 | In sum, the results suggested that metformin can ameliorate the MC-LR-induced AD-like phenotype by preventing tau phosphorylation at Ser202, which was mainly mediated by mTOR-dependent PP2A and GSK-3beta activation. | Metformin | glycogen synthase kinase 3 alpha | Homo sapiens |