Title : Melatonin reduces inflammation in intestinal cells, organoids and intestinal explants.

Pub. Date : 2021 Oct

PMID : 34431007






2 Functional Relationships(s)
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1 It was found that different concentrations of melatonin could significantly inhibit the expression levels of NFkappaB and its downstream cytokines, including IL6 and IL8 in Caco-2 cells (*P < 0.05, **P < 0.01), 3D intestinal organoids (*P < 0.05, **P < 0.01) and intestinal explants (*P < 0.05, **P < 0.01). Melatonin C-X-C motif chemokine ligand 8 Homo sapiens
2 Melatonin abolished the activation of LPS on the expression levels of NFkappaB, IL6, and IL8 in three intestinal models (*P < 0.05, **P < 0.01, ***P < 0.001). Melatonin C-X-C motif chemokine ligand 8 Homo sapiens