Title : S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity.

Pub. Date : 2021 Oct

PMID : 34428449






2 Functional Relationships(s)
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1 The Spike protein of SARS-CoV-2, the causative agent of COVID-19, has the most cysteine-rich cytoplasmic tail among known human pathogens in the closely-related family of beta-coronaviruses; however, it is unclear which of the cytoplasmic cysteines are S-acylated or the impact of this modification on viral infectivity. Cysteine surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 Here we identify specific cysteine clusters in the Spike protein of SARS-CoV-2 that are targets of S-acylation. Cysteine surface glycoprotein Severe acute respiratory syndrome coronavirus 2