Pub. Date : 2021 Dec
PMID : 34425095
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-144 silencing selectively reduced the activities of both SDH and FH resulting in the accumulation of their related substrates succinate and fumarate. | Fumarates | microRNA 144 | Homo sapiens |
| 2 | Combined, these results demonstrate that silencing of miR-144 inhibits the activity of NRF2 through decreased fumarate production in obesity. | Fumarates | microRNA 144 | Homo sapiens |
| 3 | CONCLUSIONS: Herein we unravel a novel mechanism whereby miR-144 inhibits NRF2 activity through the consumption of fumarate by activation of FH. | Fumarates | microRNA 144 | Homo sapiens |