Title : Metformin Potentiates the Effects of Anlotinib in NSCLC via AMPK/mTOR and ROS-Mediated Signaling Pathways.

Pub. Date : 2021

PMID : 34421608






4 Functional Relationships(s)
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1 Metformin Potentiates the Effects of Anlotinib in NSCLC via AMPK/mTOR and ROS-Mediated Signaling Pathways. Metformin protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens
2 Interesting, metformin also exerts broad anticancer effects through the activation of AMP-activated protein kinase (AMPK) and inhibition of mammalian target of rapamycin (mTOR). Metformin protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens
3 Interesting, metformin also exerts broad anticancer effects through the activation of AMP-activated protein kinase (AMPK) and inhibition of mammalian target of rapamycin (mTOR). Metformin protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens
4 Moreover, anlotinib combined with metformin induced apoptosis and oxidative stress, which was associated with the activation of AMPK and inhibition of mTOR. Metformin protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens