Title : Effect of Menadione and Combination of Gemcitabine and Cisplatin on Cancer Stem Cells in Human Non-small Cell Lung Cancer (NSCLC) Cell Line A549.

Pub. Date : 2021 Winter

PMID : 34400945






2 Functional Relationships(s)
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1 Quantitative RT-PCR showed significant downregulation of CSC markers (Oct4, Nanog, Sox2, Aldh1, Abcb1, CD44, and CD133) and Snail, epithelial-mesenchymal transition marker, after treatment with menadione and cisplatin/gemcitabine. Cisplatin CD44 molecule (Indian blood group) Homo sapiens
2 Flow cytometry showed CD44-positive cells that constitute a high percentage (70%) of A549 cells reduced significantly after treatment with cisplatin/gemcitabine or menadione. Cisplatin CD44 molecule (Indian blood group) Homo sapiens