Title : NLRP3 Overexpression Associated With Poor Prognosis and Presented as an Effective Therapeutic Target in Osteosarcoma.

Pub. Date : 2021

PMID : 34393801






3 Functional Relationships(s)
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1 Western blot was performed to evaluate the expression of NLRP3 and the related proteins in osteosarcoma cell lines after the blockade of NLRP3 using CY-09 and lentivirus intervention. CY5.5 cyanine dye NLR family pyrin domain containing 3 Homo sapiens
2 Western blot was performed to evaluate the expression of NLRP3 and the related proteins in osteosarcoma cell lines after the blockade of NLRP3 using CY-09 and lentivirus intervention. CY5.5 cyanine dye NLR family pyrin domain containing 3 Homo sapiens
3 Moreover, NLRP3 suppression by the inhibitor of CY-09 or lentivirus-induced gene knockdown inhibited the cell proliferation, migration, invasion and promoted the cell apoptosis and G1 cell cycle arrest in osteosarcoma via targeting the inflammasome pathway. CY5.5 cyanine dye NLR family pyrin domain containing 3 Homo sapiens