Pub. Date : 2021 Oct
PMID : 34388523
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate. | Metformin | solute carrier family 47 member 1 | Homo sapiens |
| 2 | Metformin pharmacokinetics is carried out by members of the membrane transporters superfamily (SLCs), being the multidrug and toxin extrusion protein 1 (MATE1), one of the most studied. | Metformin | solute carrier family 47 member 1 | Homo sapiens |
| 3 | Metformin pharmacokinetics is carried out by members of the membrane transporters superfamily (SLCs), being the multidrug and toxin extrusion protein 1 (MATE1), one of the most studied. | Metformin | solute carrier family 47 member 1 | Homo sapiens |
| 4 | Some genetic variants in MATE1 have been associated with reduced in vitro metformin transport. | Metformin | solute carrier family 47 member 1 | Homo sapiens |
| 5 | To elucidate the metformin pharmacogenetics, a children cohort was genotyped, allowing us to describe, for the first time, a MATE1 rs77474263 TT homozygous individual. | Metformin | solute carrier family 47 member 1 | Homo sapiens |