Title : Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice.

Pub. Date : 2022 Feb

PMID : 34387888






1 Functional Relationships(s)
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1 Intestinal inflammation and ileal mRNAs (Nr1h4, Fgf15 and Ostalpha) were not different among groups, supporting a liver specific effect of GW4064 in this model CONCLUSION: GW4064 prevents PNAC in mice through restoration of hepatic FXR signaling resulting in increased expression of canalicular bile, sterol and phospholipid transporters, and suppression of macrophage recruitment and activation. GW 4064 fibroblast growth factor 15 Mus musculus