Pub. Date : 2021 Dec
PMID : 34386930
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of STAT3 level ameliorated the inhibitive effects of miR-4458 on cells proliferation and PD-L1 expression in cells. | mir-4458 | signal transducer and activator of transcription 3 | Sus scrofa |
| 2 | For in vivo studies, overexpression of miR-4458 hindered tumor growth, decreased the proportion of PD-1+ T cells, the expression of PD-L1 and IL-10, upregulated the proportion of CD4+ T, CD8+ T cells as well as the expression of IFN-gamma and IL-2, which were all reversed by overexpression of STAT3, and the effects of STAT3 were counteracted after knockdown of PD-L1. | mir-4458 | signal transducer and activator of transcription 3 | Sus scrofa |
| 3 | For in vivo studies, overexpression of miR-4458 hindered tumor growth, decreased the proportion of PD-1+ T cells, the expression of PD-L1 and IL-10, upregulated the proportion of CD4+ T, CD8+ T cells as well as the expression of IFN-gamma and IL-2, which were all reversed by overexpression of STAT3, and the effects of STAT3 were counteracted after knockdown of PD-L1. | mir-4458 | signal transducer and activator of transcription 3 | Sus scrofa |
| 4 | MiR-4458 overexpression enhanced anti-tumor immunity via targeting STAT3 to block the PD-L1/PD-1 pathway. | mir-4458 | signal transducer and activator of transcription 3 | Sus scrofa |