Title : Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis.

Pub. Date : 2021

PMID : 34385920






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation. Quercetin C-C motif chemokine ligand 2 Homo sapiens
2 Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation. Quercetin C-C motif chemokine ligand 2 Homo sapiens
3 Conclusion: Our results from both in vitro and in silico studies identified that quercetin inhibited the THP-1 monocyte migration, MCP-1, and ICAM-1 and increased cholesterol efflux probably mediated via the LXR/RXR signaling pathway. Quercetin C-C motif chemokine ligand 2 Homo sapiens