Pub. Date : 2021 Sep 1
PMID : 34385259
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the second S phase, BRCA1/2-deficient cells are unable to suppress origin firing through ATR, resulting in continuous DNA synthesis and more DSBs. | dsbs | BRCA1 DNA repair associated | Homo sapiens |
| 2 | Thus, PARPi induces DSBs progressively through trans cell cycle ssDNA gaps, and BRCA1/2-deficient cells fail to slow down and repair DSBs over multiple cell cycles, explaining the unique efficacy of PARPi in BRCA1/2-deficient cells. | dsbs | BRCA1 DNA repair associated | Homo sapiens |